Author: timmcdaniels

Public Health

Poison Centers See Nearly 400% Increase in Liver Injury Calls

A new UVA Health study reveals that calls to poison centers involving liver injuries from medications, supplements, alcohol, and other substances surged nearly 400% between 2000 and 2024. Acetaminophen was the leading cause, with suspected suicide the most common reason for exposure. Alcohol ranked second, with cases rising during the COVID-19 pandemic. Over 80% of cases required inpatient care.

Dementia

Discovery Explains Link Between Post-Surgery Delirium, Dementia

UVA Health researchers have discovered how postoperative delirium may trigger dementia in older patients and identified a potential drug to reverse the underlying brain changes. The study found that anesthesia, surgery, and intensive care stress alter gene activity in aged brains, disrupting memory and sleep regulation. Vorinostat, an FDA-approved cancer drug, reversed many of these harmful changes in mice.

Public Health

UVA, Qnovia Reach Agreement on Worldwide Exclusive License

Qnovia, Inc., a clinical-stage pharmaceutical company, today announced it has secured a worldwide exclusive license to an innovative antimicrobial peptide from the University of Virginia Licensing & Ventures Group. The license marks Qnovia’s expansion into a second major therapeutic area, complementing its lead smoking cessation program as the company pursues breakthrough solutions to population-scale health challenges.

Neuroscience

Shooting for the Stars: UVA Lab’s New Gene Therapy May End Pediatric Seizures

When University of Virginia graduate student Caeley Reever came across the word “stellular” – “little star” in Latin – she and UVA anesthesiology professor Manoj Patel knew they had the perfect name for their startup company.

Stellula Therapeutics is centered around developing a gene therapy for a rare pediatric genetic epilepsy disorder, SCN8A developmental and epileptic encephalopathy.